Search results for "cocaine use disorder"
showing 2 items of 2 documents
Bilateral Transcranial Magnetic Stimulation of the Prefrontal Cortex Reduces Cocaine Intake: A Pilot Study
2016
Background Chronic cocaine consumption is associated with a decrease in mesolimbic dopamine transmission that maintains drug intake. transcranial magnetic stimulation (TMS) is gaining reliability, a useful therapeutic tool in drug addiction, since it can modulate cortico-limbic activity resulting in reduction of drug craving. Aims In the present study, we investigated the therapeutic effect of bilateral TMS of prefrontal cortex (PFC) in reducing cocaine intake, in a sample of treatment-seeking patients with current cocaine use disorder (DSM-V). Methods Ten cocaine addicts (DSM-V) were randomly assigned to the active or sham stimulation protocol in a double-blind experimental design. Twelve …
Characterization and enhancement of resilience to the effects of social stress on the rewarding properties of cocaine in male mice
2022
El principal foco de interés en la presente Tesis Doctoral es estudiar la resiliencia a desarrollar un trastorno por consumo de cocaína tras la exposición a estrés. Para ello utilizamos modelos animales de estrés social (la derrota social repetida intermitente, DSRI) y de efectos reforzantes de las drogas (el paradigma de Condicionamiento de Preferencia de Lugar, CPL), ya que en estudios previos hemos demostrado que la exposición a DSRI incrementa los efectos reforzantes de la cocaína en el CPL (García-Pardo y cols., 2019; Calpe-López y cols., 2020). Nuestro objetivo es identificar a los animales resilientes a este efecto de la DSRI, caracterizar su comportamiento tras el estrés, estudiar s…